anguish
/ˈæŋ.ɡwɪʃ/noun
Deep, intense suffering of the body or the mind.
Example sentences
- “The parents waited in anguish for news of their missing son.”
- “The anguish in her voice told us the news from the hospital was bad.”
Heavier and more literary than "distress", and more often mental than physical. People cry out "in anguish".